CLOZAPINE N-OXIDE
CAS No. 34233-69-7
CLOZAPINE N-OXIDE ( Clozapine N-oxide )
Catalog No. M18447 CAS No. 34233-69-7
Clozapine N-oxide is a major metabolite of clozapine that can be detected in the earliest excretion time interval after clozapine administration.
Purity : 98%
Size | Price / USD | Stock | Quantity |
2MG | 27 | In Stock |
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5MG | 41 | In Stock |
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10MG | 68 | In Stock |
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25MG | 113 | In Stock |
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50MG | 168 | In Stock |
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100MG | 250 | In Stock |
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200MG | Get Quote | In Stock |
|
500MG | Get Quote | In Stock |
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1G | Get Quote | In Stock |
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Biological Information
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Product NameCLOZAPINE N-OXIDE
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NoteResearch use only, not for human use.
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Brief DescriptionClozapine N-oxide is a major metabolite of clozapine that can be detected in the earliest excretion time interval after clozapine administration.
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DescriptionClozapine N-oxide is a major metabolite of clozapine that can be detected in the earliest excretion time interval after clozapine administration. It is produced by the action of cytochrome P450 (CYP) isoforms CYP1A2 and CYP3A4, whose activities, in turn, can be affected by drugs and disease. Clozapine N-oxide is normally biologically inactive. However, it can be used in designer receptor exclusively activated by designer drugs, also known as DREADDs, technology to modulate synthetic receptors in vivo.
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SynonymsClozapine N-oxide
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PathwayOthers
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TargetOther Targets
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RecptorOthers
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Research AreaNeurological Disease
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Indication——
Chemical Information
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CAS Number34233-69-7
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Formula Weight342.82
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Molecular FormulaC18H19ClN4O
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Purity98%
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SolubilityDMSO : ≥ 100 mg/mL 291.70 mM; Methanol : ≥ 28.6 mg/mL 83.43 mM H2O : 1 mg/mL2.92 mM;
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SMILESClc1ccc2Nc4ccccc4C(=Nc2c1)N3CC[N+]([O-])(C)CC3
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Chemical Name3-Chloro-6-(4-methyl-4-oxidopiperazin-4-ium-1-yl)-5H-benzo[b][1,4]benzodiazepine
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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Syk Inhibitor II hyd...
The impact of spleen tyrosine kinase (Syk) signaling might be prominent in lupus because (i) Syk is a shared downstream signaling molecule among circulating immune complex, LPS, and (1→3)-β-D-glucan (BG), and (ii) all of these factors are detectable in the serum of Fc gamma receptor IIb-deficient (FcgRIIb-/-) mice with sepsis. Syk inhibition downregulated several inflammatory pathways in FcgRIIb-/- macrophages activated with BG + LPS suggesting the potential anti-inflammatory impact of Syk inhibitors in lupus.
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